Influenza virus specific human antibody repertoire studies
Identifieur interne : 000075 ( Main/Exploration ); précédent : 000074; suivant : 000076Influenza virus specific human antibody repertoire studies
Auteurs : James E. Crowe [États-Unis]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2019.
Abstract
The diversity of antigen specific adaptive receptors on the surface of B cells and in the population of secreted antibodies is enormous, but increasingly we are acquiring the technical capability to interrogate antibody repertoires in great detail. These antibody technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system, because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing antibody repertoires at great depth is helping us to understand the central features of influenza immunity.
Url:
DOI: 10.4049/jimmunol.1801459
PubMed: 30617118
PubMed Central: 6327975
Affiliations:
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Crowe</name><affiliation wicri:level="1"><nlm:aff id="A1">Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232</wicri:regionArea><wicri:noRegion>37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232</wicri:regionArea><wicri:noRegion>37232</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232</wicri:regionArea><wicri:noRegion>37232</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><idno type="eISSN">1550-6606</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The diversity of antigen specific adaptive receptors on the surface of B cells and in the population of secreted antibodies is enormous, but increasingly we are acquiring the technical capability to interrogate antibody repertoires in great detail. These antibody technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system, because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing antibody repertoires at great depth is helping us to understand the central features of influenza immunity.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name></noRegion><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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